Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis

Por Gurden, Mark D., Anderhub, Simon J., Faisal, Amir, Linardopoulos, Spiros
Publicado no Oncotarget (2016)

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses

Por Dolly, Saoirse O, Gurden, Mark D, Drosopoulos, Konstantinos, Clarke, Paul, de Bono, Johann, Kaye, Stan, Workman, Paul, Linardopoulos, Spiros
Publicado no Br J Cancer (2017)

Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F

Por Gurden, Mark D. J., Holland, Andrew J., van Zon, Wouter, Tighe, Anthony, Vergnolle, Mailys A., Andres, Douglas A., Spielmann, H. Peter, Malumbres, Marcos, Wolthuis, Rob M. F., Cleveland, Don W., Taylor, Stephen S.
Publicado em 2010

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

Por Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros
Publicado no Br J Cancer (2017)

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Por Naud, Sébastien, Westwood, Isaac M., Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J., Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A., Raynaud, Florence I., Linardopoulos, Spiros, van Montfort, Rob L. M., Blagg, Julian
Publicado em 2013