A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

Por Geurink, Paul P, Oualid, El Farid, Jonker, Anika, Hameed, Dharjath S, Ovaa, Huib
Publicado em 2012

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

Por Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David
Publicado no Mol Cell (2016)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

Por Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Cancer Chemother Pharmacol (2015)

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

Por Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Publicado no Cell Chem Biol (2016)

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

Por Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Publicado em 2013

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

Por Geurink, Paul P., Liu, Nora, Spaans, Michiel P., Downey, Sondra L., van den Nieuwendijk, Adrianus M. C. H., van der Marel, Gijsbert A., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Publicado em 2010

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

Por Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Publicado em 2013

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

Por Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib
Publicado no Chembiochem (2016)

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

Por Screen, Michael, Britton, Matthew, Downey, Sondra L., Verdoes, Martijn, Voges, Mathias J., Blom, Annet E. M., Geurink, Paul P., Risseeuw, Martijn D. P., Florea, Bogdan I., van der Linden, Wouter A., Pletnev, Alexandre A., Overkleeft, Herman S., Kisselev, Alexei F.
Publicado em 2010

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

Por Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Haematologica (2015)

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

Por Banno, Asoka, Garcia, Daniel A., van Baarsel, Eric D., Metz, Patrick J., Fisch, Kathleen, Widjaja, Christella E., Kim, Stephanie H., Lopez, Justine, Chang, Aaron N., Geurink, Paul P., Florea, Bogdan I., Overkleeft, Hermen S., Ovaa, Huib, Bui, Jack D., Yang, Jing, Chang, John T.
Publicado no Oncotarget (2016)

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Por Mevissen, Tycho E.T., Kulathu, Yogesh, Mulder, Monique P.C., Geurink, Paul P., Maslen, Sarah L., Gersch, Malte, Elliott, Paul R., Burke, John E., van Tol, Bianca D.M., Akutsu, Masato, Oualid, Farid El, Kawasaki, Masato, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Publicado no Nature (2016)

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

Por Florea, Bogdan I., Verdoes, Martijn, Li, Nan, van der Linden, Wouter A., Geurink, Paul P., van den Elst, Hans, Hofmann, Tanja, de Ru, Arnoud, van Veelen, Peter A., Tanaka, Keiji, Sasaki, Katsuhiro, Murata, Shigeo, den Dulk, Hans, Brouwer, Jaap, Ossendorp, Ferry A., Kisselev, Alexei F., Overkleeft, Herman S.
Publicado em 2010

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Por Geurink, Paul P., van der Linden, Wouter A., Mirabella, Anne C., Gallastegui, Nerea, de Bruin, Gerjan, Blom, Annet E. M., Voges, Mathias J., Mock, Elliot D., Florea, Bogdan I., van der Marel, Gijs A., Driessen, Christoph, van der Stelt, Mario, Groll, Michael, Overkleeft, Herman S., Kisselev, Alexei F.
Publicado em 2013