Catching a DUB in the act: novel ubiquitin-based active site directed probes

di Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Pubblicato in Curr Opin Chem Biol (2014)

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

di Geurink, Paul P, Oualid, El Farid, Jonker, Anika, Hameed, Dharjath S, Ovaa, Huib
Pubblicazione 2012

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

di Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David
Pubblicato in Mol Cell (2016)

Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation

di Palmer, Amy L., de Jong, Annemieke, Leestemaker, Yves, Geurink, Paul P., Wijdeven, Ruud H., Ovaa, Huib, Dolan, Brian P.
Pubblicato in J Immunol (2017)

Profiling DUBs and Ubl-specific proteases with activity-based probes

di Geurink, Paul P., van der Heden van Noort, Gerbrand J., Mulder, Monique P.C., Knaap, Robert C.M., Kikkert, Marjolein, Ovaa, Huib
Pubblicato in Methods Enzymol (2019)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

di Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Pubblicato in Cancer Chemother Pharmacol (2015)

Quantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry

di Brunner, Andrea M., Lössl, Philip, Geurink, Paul P., Ovaa, Huib, Albanese, P., Altelaar, A.F. Maarten, Heck, Albert J.R., Scheltema, Richard A.
Pubblicato in Mol Cell Proteomics (2021)

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

di Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Pubblicato in Cell Chem Biol (2016)

Structural basis of the specificity of USP18 toward ISG15

di Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter
Pubblicato in Nat Struct Mol Biol (2017)

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

di Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P.
Pubblicato in J Am Chem Soc (2020)

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

di Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Pubblicazione 2013

Identification and characterization of diverse OTU deubiquitinases in bacteria

di Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Pubblicato in EMBO J (2020)

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

di Geurink, Paul P., Liu, Nora, Spaans, Michiel P., Downey, Sondra L., van den Nieuwendijk, Adrianus M. C. H., van der Marel, Gijsbert A., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Pubblicazione 2010

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

di Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Pubblicato in Nat Commun (2019)

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

di Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Pubblicazione 2013

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

di Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib
Pubblicato in Chembiochem (2016)

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

di Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Pubblicato in Proc Natl Acad Sci U S A (2018)

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

di Screen, Michael, Britton, Matthew, Downey, Sondra L., Verdoes, Martijn, Voges, Mathias J., Blom, Annet E. M., Geurink, Paul P., Risseeuw, Martijn D. P., Florea, Bogdan I., van der Linden, Wouter A., Pletnev, Alexandre A., Overkleeft, Herman S., Kisselev, Alexei F.
Pubblicazione 2010

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

di Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Pubblicato in Haematologica (2015)

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

di Banno, Asoka, Garcia, Daniel A., van Baarsel, Eric D., Metz, Patrick J., Fisch, Kathleen, Widjaja, Christella E., Kim, Stephanie H., Lopez, Justine, Chang, Aaron N., Geurink, Paul P., Florea, Bogdan I., Overkleeft, Hermen S., Ovaa, Huib, Bui, Jack D., Yang, Jing, Chang, John T.
Pubblicato in Oncotarget (2016)