Catching a DUB in the act: novel ubiquitin-based active site directed probes

Por Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Publicado no Curr Opin Chem Biol (2014)

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

Por Geurink, Paul P, Oualid, El Farid, Jonker, Anika, Hameed, Dharjath S, Ovaa, Huib
Publicado em 2012

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

Por Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David
Publicado no Mol Cell (2016)

Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation

Por Palmer, Amy L., de Jong, Annemieke, Leestemaker, Yves, Geurink, Paul P., Wijdeven, Ruud H., Ovaa, Huib, Dolan, Brian P.
Publicado no J Immunol (2017)

Profiling DUBs and Ubl-specific proteases with activity-based probes

Por Geurink, Paul P., van der Heden van Noort, Gerbrand J., Mulder, Monique P.C., Knaap, Robert C.M., Kikkert, Marjolein, Ovaa, Huib
Publicado no Methods Enzymol (2019)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

Por Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Cancer Chemother Pharmacol (2015)

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

Por Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Publicado no Cell Chem Biol (2016)

Structural basis of the specificity of USP18 toward ISG15

Por Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter
Publicado no Nat Struct Mol Biol (2017)

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

Por Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P.
Publicado no J Am Chem Soc (2020)

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

Por Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Publicado em 2013

Identification and characterization of diverse OTU deubiquitinases in bacteria

Por Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Publicado no EMBO J (2020)

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

Por Geurink, Paul P., Liu, Nora, Spaans, Michiel P., Downey, Sondra L., van den Nieuwendijk, Adrianus M. C. H., van der Marel, Gijsbert A., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Publicado em 2010

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Por Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Publicado no Nat Commun (2019)

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

Por Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Publicado em 2013

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

Por Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib
Publicado no Chembiochem (2016)

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

Por Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Publicado no Proc Natl Acad Sci U S A (2018)

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

Por Screen, Michael, Britton, Matthew, Downey, Sondra L., Verdoes, Martijn, Voges, Mathias J., Blom, Annet E. M., Geurink, Paul P., Risseeuw, Martijn D. P., Florea, Bogdan I., van der Linden, Wouter A., Pletnev, Alexandre A., Overkleeft, Herman S., Kisselev, Alexei F.
Publicado em 2010

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

Por Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Haematologica (2015)

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

Por Banno, Asoka, Garcia, Daniel A., van Baarsel, Eric D., Metz, Patrick J., Fisch, Kathleen, Widjaja, Christella E., Kim, Stephanie H., Lopez, Justine, Chang, Aaron N., Geurink, Paul P., Florea, Bogdan I., Overkleeft, Hermen S., Ovaa, Huib, Bui, Jack D., Yang, Jing, Chang, John T.
Publicado no Oncotarget (2016)

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Por Mevissen, Tycho E.T., Kulathu, Yogesh, Mulder, Monique P.C., Geurink, Paul P., Maslen, Sarah L., Gersch, Malte, Elliott, Paul R., Burke, John E., van Tol, Bianca D.M., Akutsu, Masato, Oualid, Farid El, Kawasaki, Masato, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Publicado no Nature (2016)