A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i

Por Huber, Eva M, Heinemeyer, Wolfgang, de Bruin, Gerjan, Overkleeft, Herman S, Groll, Michael
Publicado no EMBO J (2016)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

Por Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Cancer Chemother Pharmacol (2015)

Inhibition of the proteasome β2 site sensitizes triple-negative breast cancer cells to β5 inhibitors through a mechanism involving Nrf1 suppression

Por Weyburne, Emily S., Wilkins, Owen M., Sha, Zhe, Williams, David A., Pletnev, Alexandre A., de Bruin, Gerjan, Overkleeft, Hermann S., Goldberg, Alfred L., Cole, Michael D., Kisselev, Alexei F.
Publicado no Cell Chem Biol (2017)

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

Por Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Haematologica (2015)

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Por Geurink, Paul P., van der Linden, Wouter A., Mirabella, Anne C., Gallastegui, Nerea, de Bruin, Gerjan, Blom, Annet E. M., Voges, Mathias J., Mock, Elliot D., Florea, Bogdan I., van der Marel, Gijs A., Driessen, Christoph, van der Stelt, Mario, Groll, Michael, Overkleeft, Herman S., Kisselev, Alexei F.
Publicado em 2013