Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

Por Kisselev, Alexei F., van der Linden, Wouter A., Overkleeft, Herman S.
Publicado em 2012

Bifunctional probes of cathepsin protease activity and pH reveal alterations in endolysosomal pH during bacterial infection

Por Sanman, Laura E., van der Linden, Wouter A., Verdoes, Martijn, Bogyo, Matthew
Publicado no Cell Chem Biol (2016)

Design and synthesis of activity-based probes and inhibitors for bleomycin hydrolase

Por van der Linden, Wouter A., Segal, Ehud, Child, Matthew A., Byzia, Anna, Drąg, Marcin, Bogyo, Matthew
Publicado no Chem Biol (2015)

An improved quenched fluorescent probe for imaging of cysteine cathepsin activity

Por Verdoes, Martijn, Bender, Kristina Oresic, Segal, Ehud, van der Linden, Wouter A., Syed, Salahuddin, Withana, Nimali P., Sanman, Laura E., Bogyo, Matthew
Publicado em 2013

Global analysis of palmitoylated proteins in Toxoplasma gondii

Por Foe, Ian T., Child, Matthew A., Majmudar, Jaimeen D., Krishnamurthy, Shruthi, van der Linden, Wouter A., Ward, Gary E., Martin, Brent R., Bogyo, Matthew
Publicado no Cell Host Microbe (2015)

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

Por Edgington-Mitchell, Laura E., Rautela, Jai, Duivenvoorden, Hendrika M., Jayatilleke, Krishnath M., van der Linden, Wouter A., Verdoes, Martijn, Bogyo, Matthew, Parker, Belinda S.
Publicado no Oncotarget (2015)

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

Por Sanman, Laura E, Qian, Yu, Eisele, Nicholas A, Ng, Tessie M, van der Linden, Wouter A, Monack, Denise M, Weerapana, Eranthie, Bogyo, Matthew
Publicado no eLife (2016)

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

Por van der Linden, Wouter A., Schulze, Christopher J., Herbert, Andrew S., Krause, Tyler B., Wirchnianski, Ariel A., Dye, John M., Chandran, Kartik, Bogyo, Matthew
Publicado no ACS Infect Dis (2016)

Detection of Intestinal Cancer by local, topical application of a Quenched Fluorescence Probe for Cysteine Cathepsins

Por Segal, Ehud, Prestwood, Tyler R., van der Linden, Wouter A., Carmi, Yaron, Bhattacharya, Nupur, Withana, Nimail, Verdoes, Martijn, Habtezion, Aida, Engleman, Edgar G., Bogyo, Matthew
Publicado no Chem Biol (2015)

A panel of subunit-selective activity-based proteasome probes

Por Verdoes, Martijn, Willems, Lianne I., van der Linden, Wouter A., Duivenvoorden, Boudewijn A., van der Marel, Gijsbert A., Florea, Bogdan I., Kisselev, Alexei F., Overkleeft, Herman S.
Publicado em 2010

Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

Por Li, Hao, van der Linden, Wouter A., Verdoes, Martijn, Florea, Bogdan I., McAllister, Fiona E., Govindaswamy, Kavitha, Elias, Joshua E., Bhanot, Purnima, Overkleeft, Herman S., Bogyo, Matthew
Publicado em 2014

Structure and function based design of Plasmodium-selective proteasome inhibitors

Por Li, Hao, O'Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew
Publicado no Nature (2016)

Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones

Por van der Linden, Wouter A., Willems, Lianne I., Shabaneh, Tamer B., Li, Nan, Ruben, Mark, Florea, Bogdan I., van der Marel, Gijs A., Kaiser, Markus, Kisselev, Alexei F., Overkleeft, Herman S.
Publicado em 2011

Azido-BODIPY Acid Reveals Quantitative Staudinger–Bertozzi Ligation in Two-Step Activity-Based Proteasome Profiling

Por Verdoes, Martijn, Florea, Bogdan I., Hillaert, Ulrik, Willems, Lianne I., van der Linden, Wouter A., Sae-Heng, Myra, Filippov, Dmitri V., Kisselev, Alexei F., van der Marel, Gijsbert A., Overkleeft, Herman S.
Publicado em 2008

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1

Por Child, Matthew A., Garland, Megan, Foe, Ian, Madzelan, Peter, Treeck, Moritz, van der Linden, Wouter A., Oresic Bender, Kristina, Weerapana, Eranthie, Wilson, Mark A., Boothroyd, John C., Reese, Michael L., Bogyo, Matthew
Publicado no mBio (2017)

Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization

Por Bender, Kristina Oresic, Ofori, Leslie, van der Linden, Wouter A., Mock, Elliot D., Data, Gopal, Chowdhury, Somenath, Li, Hao, Segal, Ehud, Lopez, Mateo Sanchez, Ellman, Jonathan A., Figdor, Carl G., Bogyo, Matthew, Verdoes, Martijn
Publicado no J Am Chem Soc (2015)

Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2

Por Wiemhoefer, Anne, Stargardt, Anita, van der Linden, Wouter A., Renner, Maria C., van Kesteren, Ronald E., Stap, Jan, Raspe, Marcel A., Tomkinson, Birgitta, Kessels, Helmut W., Ovaa, Huib, Overkleeft, Herman S., Florea, Bogdan, Reits, Eric A.
Publicado no Mol Cell Proteomics (2015)

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

Por Screen, Michael, Britton, Matthew, Downey, Sondra L., Verdoes, Martijn, Voges, Mathias J., Blom, Annet E. M., Geurink, Paul P., Risseeuw, Martijn D. P., Florea, Bogdan I., van der Linden, Wouter A., Pletnev, Alexandre A., Overkleeft, Herman S., Kisselev, Alexei F.
Publicado em 2010

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

Por Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado no Haematologica (2015)

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

Por Florea, Bogdan I., Verdoes, Martijn, Li, Nan, van der Linden, Wouter A., Geurink, Paul P., van den Elst, Hans, Hofmann, Tanja, de Ru, Arnoud, van Veelen, Peter A., Tanaka, Keiji, Sasaki, Katsuhiro, Murata, Shigeo, den Dulk, Hans, Brouwer, Jaap, Ossendorp, Ferry A., Kisselev, Alexei F., Overkleeft, Herman S.
Publicado em 2010