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Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

Proteasomes are large, multisubunit proteolytic complexes presenting multiple targets for therapeutic intervention. The 26S proteasome consists of a 20S proteolytic core and one or two 19S regulatory particles. The 20S core contains three types of active sites. Many structurally diverse inhibitors o...

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Autori principali: Kisselev, Alexei F., van der Linden, Wouter A., Overkleeft, Herman S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503453/
https://ncbi.nlm.nih.gov/pubmed/22284358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.01.003
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