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Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Proteasomes are large, multisubunit proteolytic complexes presenting multiple targets for therapeutic intervention. The 26S proteasome consists of a 20S proteolytic core and one or two 19S regulatory particles. The 20S core contains three types of active sites. Many structurally diverse inhibitors o...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3503453/ https://ncbi.nlm.nih.gov/pubmed/22284358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.01.003 |
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