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Subunit specific inhibitors of proteasomes and their potential for immunomodulation

Specialized variants of the constitutive 20S proteasome in the immune system like the immunoproteasomes and the thymoproteasome contain active site-bearing subunits which differ in their cleavage priorities and substrate binding pockets. The immunoproteasome plays a crucial role in antigen processin...

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Dades bibliogràfiques
Publicat a:Curr Opin Chem Biol
Autors principals: Kisselev, Alexei F, Groettrup, Marcus
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564373/
https://ncbi.nlm.nih.gov/pubmed/25217863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2014.08.012
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