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Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones

Syringolins, a class of natural products, potently and selectively inhibit the proteasome and show promising antitumour activity. To gain insight in the mode of action of syringolins, the ureido structural element present in syringolins is incorporated in oligopeptide vinyl sulfones and peptide epox...

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Detalhes bibliográficos
Main Authors: van der Linden, Wouter A., Willems, Lianne I., Shabaneh, Tamer B., Li, Nan, Ruben, Mark, Florea, Bogdan I., van der Marel, Gijs A., Kaiser, Markus, Kisselev, Alexei F., Overkleeft, Herman S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769973/
https://ncbi.nlm.nih.gov/pubmed/22105930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1ob06554h
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