Structure and function based design of Plasmodium-selective proteasome inhibitors

The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation(1). Compounds that target the proteasome are potentially valuable tools for the treatment of pathogens that depend on proteasome function for survival and rep...

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Foilsithe in:Nature
Main Authors: Li, Hao, O'Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755332/
https://ncbi.nlm.nih.gov/pubmed/26863983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16936
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