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Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome

[Image: see text] We have identified short N,C-capped peptides that selectively inhibit the proteasome of the malaria-causing pathogen Plasmodium falciparum. These compounds are highly potent in culture with no toxicity in host cells. One cyclic biphenyl ether compound inhibited intraerythrocytic gr...

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Detalhes bibliográficos
Main Authors: Li, Hao, Tsu, Christopher, Blackburn, Christopher, Li, Gang, Hales, Paul, Dick, Lawrence, Bogyo, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183598/
https://ncbi.nlm.nih.gov/pubmed/25226494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507692y
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