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Oxadiazole-isopropylamides as Potent and Non-covalent Proteasome Inhibitors
Screening of the 50,000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide 1 (PI-1833) which inhibited CT-L activity (IC(50) 0.60 μM) with little effects on the other 2 major proteasome proteolytic activities, T-L and PGPH-L. LC/MS-MS and dialysis show that 1 is a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774303/ https://ncbi.nlm.nih.gov/pubmed/23547706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400221d |
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