Synthesis and Biological Evaluation of Naphthoquinone Analogs as a Novel Class of Proteasome Inhibitors

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure activi...

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Bibliographische Detailangaben
Hauptverfasser: Lawrence, Harshani R., Kazi, Aslamuzzaman, Luo, Yunting, Kendig, Robert, Ge, Yiyu, Jain, Sanjula, Daniel, Kenyon, Santiago, Daniel, Guida, Wayne C., Sebti, Saïd M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530924/
https://ncbi.nlm.nih.gov/pubmed/20621484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.038
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