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An improved quenched fluorescent probe for imaging of cysteine cathepsin activity

The cysteine cathepsins are a family of proteases that play important roles in both normal cellular physiology and many human diseases. In cancer, the activity of many of the cysteine cathepsins is upregulated and can be exploited for tumor imaging. Here we present the design and synthesis of a new...

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Detalhes bibliográficos
Main Authors: Verdoes, Martijn, Bender, Kristina Oresic, Segal, Ehud, van der Linden, Wouter A., Syed, Salahuddin, Withana, Nimali P., Sanman, Laura E., Bogyo, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826460/
https://ncbi.nlm.nih.gov/pubmed/23971698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4056068
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