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Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe
Legumain is a lysosomal cysteine protease whose biological function remains poorly defined. Legumain activity is up-regulated in most human cancers and inflammatory diseases most likely as the result of high expression in populations of activated macrophages. Within the tumor microenvironment, legum...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429797/ https://ncbi.nlm.nih.gov/pubmed/23215039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307083b |
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