Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

Epithelial cells of the thymus cortex express a unique proteasome particle involved in positive T cell selection. This thymoproteasome contains the recently discovered β5t subunit that has an uncharted activity, if any. We synthesized fluorescent epoxomicin probes that were used in a chemical proteo...

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Auteurs principaux: Florea, Bogdan I., Verdoes, Martijn, Li, Nan, van der Linden, Wouter A., Geurink, Paul P., van den Elst, Hans, Hofmann, Tanja, de Ru, Arnoud, van Veelen, Peter A., Tanaka, Keiji, Sasaki, Katsuhiro, Murata, Shigeo, den Dulk, Hans, Brouwer, Jaap, Ossendorp, Ferry A., Kisselev, Alexei F., Overkleeft, Herman S.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039300/
https://ncbi.nlm.nih.gov/pubmed/20797608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.05.027
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