TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells

In the thymus, low-affinity T cell antigen receptor (TCR) engagement facilitates positive selection of a useful T cell repertoire. Here we report that TCR responsiveness of mature CD8(+) T cells is fine-tuned by their affinity for positively selecting peptides in the thymus and that optimal TCR resp...

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Publicado no:Nat Immunol
Main Authors: Takada, Kensuke, Van Laethem, Francois, Xing, Yan, Akane, Kazuyuki, Suzuki, Haruhiko, Murata, Shigeo, Tanaka, Keiji, Jameson, Stephen C., Singer, Alfred, Takahama, Yousuke
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810782/
https://ncbi.nlm.nih.gov/pubmed/26301566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3237
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