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Thymoproteasome optimizes positive selection of CD8(+) T cells without contribution of negative selection

Functionally competent and self-tolerant T cell repertoire is shaped through positive and negative selection in the cortical and medullary microenvironments of the thymus. The thymoproteasome specifically expressed in the cortical thymic epithelium is essential for the optimal generation of CD8(+) T...

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Bibliografiske detaljer
Udgivet i:Adv Immunol
Main Authors: Ohigashi, Izumi, Takahama, Yousuke
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237917/
https://ncbi.nlm.nih.gov/pubmed/33993918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.ai.2021.03.001
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