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Thymoproteasome optimizes positive selection of CD8(+) T cells without contribution of negative selection
Functionally competent and self-tolerant T cell repertoire is shaped through positive and negative selection in the cortical and medullary microenvironments of the thymus. The thymoproteasome specifically expressed in the cortical thymic epithelium is essential for the optimal generation of CD8(+) T...
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| 發表在: | Adv Immunol |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8237917/ https://ncbi.nlm.nih.gov/pubmed/33993918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.ai.2021.03.001 |
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