TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8(+) T Cells

The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes that newly express TCRs. Previous fetal thymus organ culture experiments have indicated that difference in the affinity for thymic TCR/pMHC interactions not only determines t...

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Bibliographic Details
Published in:J Immunol
Main Authors: Khanom, Umme Shahina, Ohigashi, Izumi, Fujimori, Sayumi, Kondo, Kenta, Takada, Kensuke, Takahama, Yousuke
Format: Artigo
Language:Inglês
Published: AAI 2019
Subjects:
Immune System Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680067/
https://ncbi.nlm.nih.gov/pubmed/31235550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900097
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