The thymoproteasome hardwires the TCR repertoire of CD8(+) T cells in the cortex independent of negative selection

The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8(+) T cells; however, how the thymoproteasome contributes to CD8(+) T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes...

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Vydáno v:J Exp Med
Hlavní autoři: Ohigashi, Izumi, Frantzeskakis, Melina, Jacques, Alison, Fujimori, Sayumi, Ushio, Aya, Yamashita, Fusano, Ishimaru, Naozumi, Yin, Da, Cam, Margaret, Kelly, Michael C., Awasthi, Parirokh, Takada, Kensuke, Takahama, Yousuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873839/
https://ncbi.nlm.nih.gov/pubmed/33555295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201904
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