Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms

Redirecting CD8 T cell immunity with self/tumor-specific affinity-matured T cell receptors (TCRs) is a promising approach for clinical adoptive T cell therapy, with the aim to improve treatment efficacy. Despite numerous functional-based studies, little is known about the characteristics of TCR sign...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Presotto, Danilo, Erdes, Efe, Duong, Minh Ngoc, Allard, Mathilde, Regamey, Pierre-Olivier, Quadroni, Manfredo, Doucey, Marie-Agnès, Rufer, Nathalie, Hebeisen, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694758/
https://ncbi.nlm.nih.gov/pubmed/29187853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01564
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