Molecular and cellular basis of T cell lineage commitment: An overview

بواسطة Singer, Alfred
الحاوية / القاعدة Semin Immunol (2010)

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

بواسطة Grossman, Zvi, Singer, Alfred
منشور في 1996

Basis of Treg development in the thymus

بواسطة Tai, Xuguang, Singer, Alfred
الحاوية / القاعدة Cell Cycle (2014)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

بواسطة Erman, Batu, Guinter, Terry I., Singer, Alfred
منشور في 2004

Lineage fate and intense debate: myths, models and mechanisms of CD4/CD8 lineage choice

بواسطة Singer, Alfred, Adoro, Stanley, Park, Jung-Hyun
منشور في 2008

Coreceptor gene “imprinting”: A genetic solution to a developmental dilemma in T cells

بواسطة Adoro, Stanley, Park, Jung-Hyun, Singer, Alfred
الحاوية / القاعدة Cell Cycle (2012)

MHC restriction is imposed on a diverse TCR repertoire by CD4 and CD8 coreceptors during thymic selection

بواسطة Van Laethem, François, Tikhonova, Anastasia N., Singer, Alfred
منشور في 2012

Induction of autoimmune disease in CTLA-4(−/−) mice depends on a specific CD28 motif that is required for in vivo costimulation

بواسطة Tai, Xuguang, Van Laethem, Francois, Sharpe, Arlene H., Singer, Alfred
منشور في 2007

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)

بواسطة Ashe, Jennifer M., Wiest, David L., Abe, Ryo, Singer, Alfred
منشور في 1999

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

بواسطة Bhandoola, Avinash, Dolnick, Benjamin, Fayad, Nihal, Nussenzweig, Andre, Singer, Alfred
منشور في 2000

Unraveling a Revealing Paradox: Why Major Histocompatibility Complex I–signaled Thymocytes “Paradoxically” Appear as CD4(+)8(lo) Transitional Cells During Positive Selection of CD8...

بواسطة Bosselut, Remy, Guinter, Terry I., Sharrow, Susan O., Singer, Alfred
منشور في 2003

Rôle crucial des corécepteurs CD4 et CD8 dans la reconnaissance antigénique des lymphocytes Tαβ

بواسطة Van Laethem, François, Saba, Ingrid, Tikhonova, Anastasia N., Singer, Alfred
الحاوية / القاعدة Med Sci (Paris) (2014)

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8(+) T Cells

بواسطة Yu, Qing, Erman, Batu, Bhandoola, Avinash, Sharrow, Susan O., Singer, Alfred
منشور في 2003

T Cell Receptor (TCR)-induced Death of Immature CD4(+)CD8(+) Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative...

بواسطة Punt, Jennifer A., Havran, Wendy, Abe, Ryo, Sarin, Apurva, Singer, Alfred
منشور في 1997

IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt: Impact on Thymocyte Development

بواسطة Yu, Qing, Erman, Batu, Park, Jung-Hyun, Feigenbaum, Lionel, Singer, Alfred
منشور في 2004

CD8 Coreceptor Extinction in Signaled CD4(+)CD8(+) Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes

بواسطة Cibotti, Ricardo, Bhandoola, Avinash, Guinter, Terry I., Sharrow, Susan O., Singer, Alfred
منشور في 2000

Lineage Commitment in the Thymus: Only the Most Differentiated (TCR(hi)bcl-2(hi)) Subset of CD4(+)CD8(+)Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

بواسطة Punt, Jennifer A., Suzuki, Harumi, Granger, Larry G., Sharrow, Susan O., Singer, Alfred
منشور في 1996

Regulation of MHC class I expression by Foxp3 and its effect on Treg cell function

بواسطة Mu, Jie, Tai, Xuguang, Iyer, Shankar S., Weissman, Jocelyn D., Singer, Alfred, Singer, Dinah S.
منشور في 2014

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of “ER-resident” molecular chaperones

بواسطة Wiest, David L., Bhandoola, Avinash, Punt, Jennifer, Kreibich, Gert, McKean, David, Singer, Alfred
منشور في 1997

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

بواسطة Yu, Qing, Park, Jung-Hyun, Doan, Loretta L., Erman, Batu, Feigenbaum, Lionel, Singer, Alfred
منشور في 2006