Molecular and cellular basis of T cell lineage commitment: An overview

Por Singer, Alfred
Publicado no Semin Immunol (2010)

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

Por Grossman, Zvi, Singer, Alfred
Publicado em 1996

Basis of Treg development in the thymus

Por Tai, Xuguang, Singer, Alfred
Publicado no Cell Cycle (2014)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

Por Erman, Batu, Guinter, Terry I., Singer, Alfred
Publicado em 2004

Lineage fate and intense debate: myths, models and mechanisms of CD4/CD8 lineage choice

Por Singer, Alfred, Adoro, Stanley, Park, Jung-Hyun
Publicado em 2008

Coreceptor gene “imprinting”: A genetic solution to a developmental dilemma in T cells

Por Adoro, Stanley, Park, Jung-Hyun, Singer, Alfred
Publicado no Cell Cycle (2012)

MHC restriction is imposed on a diverse TCR repertoire by CD4 and CD8 coreceptors during thymic selection

Por Van Laethem, François, Tikhonova, Anastasia N., Singer, Alfred
Publicado em 2012

Induction of autoimmune disease in CTLA-4(−/−) mice depends on a specific CD28 motif that is required for in vivo costimulation

Por Tai, Xuguang, Van Laethem, Francois, Sharpe, Arlene H., Singer, Alfred
Publicado em 2007

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)

Por Ashe, Jennifer M., Wiest, David L., Abe, Ryo, Singer, Alfred
Publicado em 1999

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

Por Bhandoola, Avinash, Dolnick, Benjamin, Fayad, Nihal, Nussenzweig, Andre, Singer, Alfred
Publicado em 2000

Unraveling a Revealing Paradox: Why Major Histocompatibility Complex I–signaled Thymocytes “Paradoxically” Appear as CD4(+)8(lo) Transitional Cells During Positive Selection of CD8...

Por Bosselut, Remy, Guinter, Terry I., Sharrow, Susan O., Singer, Alfred
Publicado em 2003

Rôle crucial des corécepteurs CD4 et CD8 dans la reconnaissance antigénique des lymphocytes Tαβ

Por Van Laethem, François, Saba, Ingrid, Tikhonova, Anastasia N., Singer, Alfred
Publicado no Med Sci (Paris) (2014)

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8(+) T Cells

Por Yu, Qing, Erman, Batu, Bhandoola, Avinash, Sharrow, Susan O., Singer, Alfred
Publicado em 2003

T Cell Receptor (TCR)-induced Death of Immature CD4(+)CD8(+) Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative...

Por Punt, Jennifer A., Havran, Wendy, Abe, Ryo, Sarin, Apurva, Singer, Alfred
Publicado em 1997

IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt: Impact on Thymocyte Development

Por Yu, Qing, Erman, Batu, Park, Jung-Hyun, Feigenbaum, Lionel, Singer, Alfred
Publicado em 2004

CD8 Coreceptor Extinction in Signaled CD4(+)CD8(+) Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes

Por Cibotti, Ricardo, Bhandoola, Avinash, Guinter, Terry I., Sharrow, Susan O., Singer, Alfred
Publicado em 2000

Lineage Commitment in the Thymus: Only the Most Differentiated (TCR(hi)bcl-2(hi)) Subset of CD4(+)CD8(+)Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

Por Punt, Jennifer A., Suzuki, Harumi, Granger, Larry G., Sharrow, Susan O., Singer, Alfred
Publicado em 1996

Regulation of MHC class I expression by Foxp3 and its effect on Treg cell function

Por Mu, Jie, Tai, Xuguang, Iyer, Shankar S., Weissman, Jocelyn D., Singer, Alfred, Singer, Dinah S.
Publicado em 2014

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of “ER-resident” molecular chaperones

Por Wiest, David L., Bhandoola, Avinash, Punt, Jennifer, Kreibich, Gert, McKean, David, Singer, Alfred
Publicado em 1997

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

Por Yu, Qing, Park, Jung-Hyun, Doan, Loretta L., Erman, Batu, Feigenbaum, Lionel, Singer, Alfred
Publicado em 2006