A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i

Inhibition of the immunoproteasome subunit β5i alleviates autoimmune diseases in preclinical studies and represents a promising new anti‐inflammatory therapy. However, the lack of structural data on the human immunoproteasome still hampers drug design. Here, we systematically determined the potency...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Huber, Eva M, Heinemeyer, Wolfgang, de Bruin, Gerjan, Overkleeft, Herman S, Groll, Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2016
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Resource
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283606/
https://ncbi.nlm.nih.gov/pubmed/27789522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695222
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