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A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
Biogenesis of the 20S proteasome is tightly regulated. The N-terminal propeptides protecting the active-site threonines are autocatalytically released only on completion of assembly. However, the trigger for the self-activation and the reason for the strict conservation of threonine as the active si...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4792962/ https://ncbi.nlm.nih.gov/pubmed/26964885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10900 |
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