Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits

[Image: see text] Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the β1c, β1i, β5c, and β5i subunits exploit the differences in the substrate-binding channels identified by...

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Udgivet i:J Med Chem
Main Authors: Xin, Bo-Tao, Huber, Eva M., de Bruin, Gerjan, Heinemeyer, Wolfgang, Maurits, Elmer, Espinal, Christofer, Du, Yimeng, Janssens, Marissa, Weyburne, Emily S., Kisselev, Alexei F., Florea, Bogdan I., Driessen, Christoph, van der Marel, Gijsbert A., Groll, Michael, Overkleeft, Herman S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378654/
https://ncbi.nlm.nih.gov/pubmed/30657666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01884
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