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A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i
Inhibition of the immunoproteasome subunit β5i alleviates autoimmune diseases in preclinical studies and represents a promising new anti‐inflammatory therapy. However, the lack of structural data on the human immunoproteasome still hampers drug design. Here, we systematically determined the potency...
Enregistré dans:
| Publié dans: | EMBO J |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5283606/ https://ncbi.nlm.nih.gov/pubmed/27789522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695222 |
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