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Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use deubiquitinases and deISGylases that reverse these modifications and antagonize host signaling processes. We here reveal that the leader pro...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5877979/ https://ncbi.nlm.nih.gov/pubmed/29463763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710617115 |
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