Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use deubiquitinases and deISGylases that reverse these modifications and antagonize host signaling processes. We here reveal that the leader pro...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877979/
https://ncbi.nlm.nih.gov/pubmed/29463763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710617115
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