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Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation
Infected or transformed cells must present peptides derived from endogenous proteins on MHC class I molecules in order to be recognized and targeted for elimination by antigen-specific cytotoxic T cells. In the first step of peptide generation, proteins are degraded by the proteasome. Here, we inves...
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| 出版年: | J Immunol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5782819/ https://ncbi.nlm.nih.gov/pubmed/29282303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700273 |
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