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Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation

Infected or transformed cells must present peptides derived from endogenous proteins on MHC class I molecules in order to be recognized and targeted for elimination by antigen-specific cytotoxic T cells. In the first step of peptide generation, proteins are degraded by the proteasome. Here, we inves...

詳細記述

保存先:
書誌詳細
出版年:J Immunol
主要な著者: Palmer, Amy L., de Jong, Annemieke, Leestemaker, Yves, Geurink, Paul P., Wijdeven, Ruud H., Ovaa, Huib, Dolan, Brian P.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782819/
https://ncbi.nlm.nih.gov/pubmed/29282303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700273
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