Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

The post-translational modification of proteins with polyubiquitin regulates virtually all aspects of cell biology. Eight distinct chain linkage types in polyubiquitin co-exist and are independently regulated in cells. This ‘ubiquitin code’ determines the fate of the modified protein1. Deubiquitinat...

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Publicado en:Nature
Autores principales: Mevissen, Tycho E.T., Kulathu, Yogesh, Mulder, Monique P.C., Geurink, Paul P., Maslen, Sarah L., Gersch, Malte, Elliott, Paul R., Burke, John E., van Tol, Bianca D.M., Akutsu, Masato, Oualid, Farid El, Kawasaki, Masato, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295632/
https://ncbi.nlm.nih.gov/pubmed/27732584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19836
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