Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Por Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah, Nowak, Radosław P., Fischer, Eric S.
Publicado no Nat Struct Mol Biol (2020)

A generic protocol for protein crystal dehydration using the HC1b humidity controller

Por Lobley, Carina M. C., Sandy, James, Sanchez-Weatherby, Juan, Mazzorana, Marco, Krojer, Tobias, Nowak, Radosław P., Sorensen, Thomas L.
Publicado no Acta Crystallogr D Struct Biol (2016)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

Por Gasic, Ivana, Groendyke, Brian J., Nowak, Radosław P., Yuan, J. Christine, Kalabathula, Joann, Fischer, Eric S., Gray, Nathanael S., Mitchison, Timothy J.
Publicado no Cells (2020)

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Por Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S
Publicado no eLife (2018)

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

Por Faust, Tyler, Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.
Publicado no Nat Chem Biol (2019)

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

Por Tarhonskaya, Hanna, Nowak, Radosław P., Johansson, Catrine, Szykowska, Aleksandra, Tumber, Anthony, Hancock, Rebecca L., Lang, Pauline, Flashman, Emily, Oppermann, Udo, Schofield, Christopher J., Kawamura, Akane
Publicado no J Mol Biol (2017)

Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library

Por Powell, Chelsea E., Du, Guangyan, Che, Jianwei, He, Zhixiang, Donovan, Katherine A., Yue, Hong, Wang, Eric S., Nowak, Radosław P., Zhang, Tinghu, Fischer, Eric S., Gray, Nathanael S.
Publicado no ACS Chem Biol (2020)

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)

Por Powell, Chelsea E., Gao, Yang, Tan, Li, Donovan, Katherine A., Nowak, Radosław P., Loehr, Amanda, Bahcall, Magda, Fischer, Eric S., Jänne, Pasi A., George, Rani E., Gray, Nathanael S.
Publicado no J Med Chem (2018)

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

Por Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Publicado no Nat Commun (2017)

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

Por Thinnes, Cyrille C., Lohans, Christopher T., Abboud, Martine I., Yeh, Tzu‐Lan, Tumber, Anthony, Nowak, Radosław P., Attwood, Martin, Cockman, Matthew E., Oppermann, Udo, Loenarz, Christoph, Schofield, Christopher J.
Publicado no Chemistry (2019)

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

Por de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.
Publicado no Nat Commun (2019)

An integrated approach to quantitative modelling in angiogenesis research

Por Connor, Anthony J., Nowak, Radosław P., Lorenzon, Erica, Thomas, Markus, Herting, Frank, Hoert, Stefan, Quaiser, Tom, Shochat, Eliezer, Pitt-Francis, Joe, Cooper, Jonathan, Maini, Philip K., Byrne, Helen M.
Publicado no J R Soc Interface (2015)

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

Por Morita, Ken, He, Shuning, Nowak, Radosław P., Wang, Jinhua, Zimmerman, Mark W., Fu, Cong, Durbin, Adam D., Martel, Megan W., Prutsch, Nicole, Gray, Nathanael S., Fischer, Eric S., Look, A. Thomas
Publicado no Cell (2020)

Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

Por Dobrovolsky, Dennis, Wang, Eric S., Morrow, Sara, Leahy, Catharine, Faust, Tyler, Nowak, Radosław P., Donovan, Katherine A., Yang, Guang, Li, Zhengnian, Fischer, Eric S., Treon, Steven P., Weinstock, David M., Gray, Nathanael S.
Publicado no Blood (2019)

Homolog-selective degradation as a strategy to probe the function of CDK6 in AML

Por Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.
Publicado no Cell Chem Biol (2018)

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations

Por Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Publicado no Angew Chem Int Ed Engl (2020)

Development and Characterization of a Wee1 Kinase Degrader

Por Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K, Fischer, Eric S., Gray, Nathanael S.
Publicado no Cell Chem Biol (2019)

Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma

Por Yue, Hong, Nowak, Radosław P, Overwijn, Daan, Payne, N Connor, Fischinger, Stephanie, Atyeo, Caroline, Baden, Lindsey R, Nilles, Eric James, Karlson, Elizabeth W, Yu, Xu G, Li, Jonathan Z, Alter, Galit, Mazitschek, Ralph, Fischer, Eric S
Publicado no medRxiv (2020)

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors

Por Korczynska, Magdalena, Le, Daniel D., Younger, Noah, Gregori-Puigjané, Elisabet, Tumber, Anthony, Krojer, Tobias, Velupillai, Srikannathasan, Gileadi, Carina, Nowak, Radosław P., Iwasa, Eriko, Pollock, Samuel B., Torres, Idelisse Ortiz, Oppermann, Udo, Shoichet, Brian K., Fujimori, Danica Galonić
Publicado no J Med Chem (2015)

Plasticity in binding confers selectivity in ligand induced protein degradation

Por Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.
Publicado no Nat Chem Biol (2018)