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Plasticity in binding confers selectivity in ligand induced protein degradation
Heterobifunctional small molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recruitment and selectivity, whi...
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| Wydane w: | Nat Chem Biol |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202246/ https://ncbi.nlm.nih.gov/pubmed/29892083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0055-y |
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