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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
The investigational drugs E7820, indisulam and tasisulam (aryl-sulfonamides) promote the degradation of the splicing factor RBM39 in a proteasome-dependent mechanism. While the activity critically depends on the Cullin RING ligase substrate receptor DCAF15, the molecular details remain elusive. Here...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6917914/ https://ncbi.nlm.nih.gov/pubmed/31686031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0378-3 |
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