Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library

Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class compounds such as thalidomide, lenalidomide, and pomalidomide to induce the degradation of neo-substrate proteins. In order to identify additional small molecule CRBN modulators, we implemented a focused combinat...

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Bibliografske podrobnosti
izdano v:ACS Chem Biol
Main Authors: Powell, Chelsea E., Du, Guangyan, Che, Jianwei, He, Zhixiang, Donovan, Katherine A., Yue, Hong, Wang, Eric S., Nowak, Radosław P., Zhang, Tinghu, Fischer, Eric S., Gray, Nathanael S.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843009/
https://ncbi.nlm.nih.gov/pubmed/32865967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00520
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