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Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators
[Image: see text] Whereas the PROTAC approach to target protein degradation greatly benefits from rational design, the discovery of small-molecule degraders relies mostly on phenotypic screening and retrospective target identification efforts. Here, we describe the design, synthesis, and screening o...
Enregistré dans:
| Publié dans: | J Med Chem |
|---|---|
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2021
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8201443/ https://ncbi.nlm.nih.gov/pubmed/34042448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01313 |
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