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Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library
Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class compounds such as thalidomide, lenalidomide, and pomalidomide to induce the degradation of neo-substrate proteins. In order to identify additional small molecule CRBN modulators, we implemented a focused combinat...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7843009/ https://ncbi.nlm.nih.gov/pubmed/32865967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00520 |
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