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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment; however, the molecular basis underlying the plei...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156078/ https://ncbi.nlm.nih.gov/pubmed/30067223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38430 |
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