Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment; however, the molecular basis underlying the plei...

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Foilsithe in:eLife
Main Authors: Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2018
Ábhair:
Biochemistry and Chemical Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156078/
https://ncbi.nlm.nih.gov/pubmed/30067223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38430
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