Development and Characterization of a Wee1 Kinase Degrader

The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic entry. Previous drug development efforts targeting...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K, Fischer, Eric S., Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980656/
https://ncbi.nlm.nih.gov/pubmed/31735695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.013
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