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Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
The PI3K/AKT signaling cascade is one of the most commonly dysregulated pathways in cancer, with over half of tumors exhibiting aberrant AKT activation. Although potent small molecule AKT inhibitors have entered clinical trials, robust and durable therapeutic responses have not been observed. As an...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980747/ https://ncbi.nlm.nih.gov/pubmed/31859249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.11.014 |
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