Development and Characterization of a Wee1 Kinase Degrader

The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic entry. Previous drug development efforts targeting...

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Vydáno v:Cell Chem Biol
Hlavní autoři: Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K, Fischer, Eric S., Gray, Nathanael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980656/
https://ncbi.nlm.nih.gov/pubmed/31735695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.013
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