Targeted protein degradation: current and future challenges

door Hanzl, Alexander, Winter, Georg E.
Gepubliceerd in Curr Opin Chem Biol (2020)

Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules

door Moser, Sarah C., Voerman, Jane S. A., Buckley, Dennis L., Winter, Georg E., Schliehe, Christopher
Gepubliceerd in Front Immunol (2018)

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

door Bensimon, Ariel, Pizzagalli, Mattia D., Kartnig, Felix, Dvorak, Vojtech, Essletzbichler, Patrick, Winter, Georg E., Superti-Furga, Giulio
Gepubliceerd in Cell Chem Biol (2020)

Selective Target Protein Degradation via Phthalimide Conjugation

door Winter, Georg E., Buckley, Dennis L., Paulk, Joshiawa, Roberts, Justin M., Souza, Amanda, Dhe-Paganon, Sirano, Bradner, James E.
Gepubliceerd in Science (2015)

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

door Dixon, Scott J., Winter, Georg E., Musavi, Leila S., Lee, Eric D., Snijder, Berend, Rebsamen, Manuele, Superti-Furga, Giulio, Stockwell, Brent R.
Gepubliceerd in ACS Chem Biol (2015)

Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

door Radic-Sarikas, Branka, Halasz, Melinda, Huber, Kilian V. M., Winter, Georg E., Tsafou, Kalliopi P., Papamarkou, Theodore, Brunak, Søren, Kolch, Walter, Superti-Furga, Giulio
Gepubliceerd in Sci Rep (2017)

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

door Hanzl, Alexander, Casement, Ryan, Imrichova, Hana, Hughes, Scott J., Barone, Eleonora, Testa, Andrea, Bauer, Sophie, Wright, Jane, Brand, Matthias, Ciulli, Alessio, Winter, Georg E.
Gepubliceerd in Nat Chem Biol (2023)

Homolog-selective degradation as a strategy to probe the function of CDK6 in AML

door Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.
Gepubliceerd in Cell Chem Biol (2018)

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

door Winter, Georg E, Rix, Uwe, Carlson, Scott M, Gleixner, Karoline V, Grebien, Florian, Gridling, Manuela, Müller, André C, Breitwieser, Florian P, Bilban, Martin, Colinge, Jacques, Valent, Peter, Bennett, Keiryn L, White, Forest M, Superti-Furga, Giulio
Gepubliceerd in 2012

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

door Winter, Georg E., Radic, Branka, Mayor-Ruiz, Cristina, Blomen, Vincent A, Trefzer, Claudia, Kandasamy, Richard K., Huber, Kilian V.M., Gridling, Manuela, Chen, Doris, Klampfl, Thorsten, Kralovics, Robert, Kubicek, Stefan, Fernandez-Capetillo, Oscar, Brummelkamp, Thijn R., Superti-Furga, Giulio
Gepubliceerd in Nat Chem Biol (2014)

Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth

door Peter, Barbara, Winter, Georg E., Blatt, Katharina, Bennett, Keiryn L., Stefanzl, Gabriele, Rix, Uwe, Eisenwort, Gregor, Hadzijusufovic, Emir, Gridling, Manuela, Dutreix, Catherine, Hoermann, Gregor, Schwaab, Juliana, Radia, Deepti, Roesel, Johannes, Manley, Paul W., Reiter, Andreas, Superti-Furga, Giulio, Valent, Peter
Gepubliceerd in Leukemia (2015)

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

door Olson, Calla M., Jiang, Baishan, Erb, Michael A., Liang, Yanke, Doctor, Zainab M., Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L., Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S., Young, Richard A., Bradner, James E., Winter, Georg E., Gray, Nathanael S.
Gepubliceerd in Nat Chem Biol (2017)

Rational discovery of molecular glue degraders via scalable chemical profiling

door Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.
Gepubliceerd in Nat Chem Biol (2020)

Acute BAF perturbation causes immediate changes in chromatin accessibility

door Schick, Sandra, Grosche, Sarah, Kohl, Katharina Eva, Drpic, Danica, Jaeger, Martin G., Marella, Nara C., Imrichova, Hana, Lin, Jung-Ming G., Hofstätter, Gerald, Schuster, Michael, Rendeiro, André F., Koren, Anna, Petronczki, Mark, Bock, Christoph, Müller, André C., Winter, Georg E., Kubicek, Stefan
Gepubliceerd in Nat Genet (2021)

LZTR1 is a regulator of RAS ubiquitination and signaling

door Bigenzahn, Johannes W., Collu, Giovanna M., Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I., Heinz, Leonhard X., Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A., Müller, André C., Winter, Georg E., Kralovics, Robert, Brummelkamp, Thijn R., Mlodzik, Marek, Superti-Furga, Giulio
Gepubliceerd in Science (2018)

Selective Mediator-dependence of cell type-specifying transcription

door Jaeger, Martin G., Schwalb, Björn, Mackowiak, Sebastian D., Velychko, Taras, Hanzl, Alexander, Imrichova, Hana, Brand, Matthias, Agerer, Benedikt, Chorn, Someth, Nabet, Behnam, Ferguson, Fleur M., Müller, André C., Bergthaler, Andreas, Gray, Nathanael S., Bradner, James E., Bock, Christoph, Hnisz, Denes, Cramer, Patrick, Winter, Georg E.
Gepubliceerd in Nat Genet (2020)

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

door Gechijian, Lara N., Buckley, Dennis L., Lawlor, Matthew A., Reyes, Jaime M., Paulk, Joshiawa, Ott, Christopher J., Winter, Georg E., Erb, Michael A., Scott, Thomas G., Xu, Mousheng, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Kwiatkowski, Nicholas P., Perry, Jennifer A., Qi, Jun, Gray, Nathanael S., Bradner, James E.
Gepubliceerd in Nat Chem Biol (2018)

The dTAG system for immediate and target-specific protein degradation

door Nabet, Behnam, Roberts, Justin M., Buckley, Dennis L., Paulk, Joshiawa, Dastjerdi, Shiva, Yang, Annan, Leggett, Alan L., Erb, Michael A., Lawlor, Matthew A., Souza, Amanda, Scott, Thomas G., Vittori, Sarah, Perry, Jennifer A., Qi, Jun, Winter, Georg E., Wong, Kwok-Kin, Gray, Nathanael S., Bradner, James E.
Gepubliceerd in Nat Chem Biol (2018)

The SWI/SNF ATPases are Required for Triple Negative Breast Cancer Cell Proliferation

door Wu, Qiong, Madany, Pasil, Akech, Jacqueline, Dobson, Jason R., Douthwright, Stephen, Browne, Gillian, Colby, Jennifer L., Winter, Georg E., Bradner, James E., Pratap, Jitesh, Sluder, Greenfield, Bhargava, Rohit, Chiosea, Simion, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B., Nickerson, Jeffrey A., Imbalzano, Anthony N.
Gepubliceerd in J Cell Physiol (2015)

MELK is not necessary for the proliferation of basal-like breast cancer cells

door Huang, Hai-Tsang, Seo, Hyuk-Soo, Zhang, Tinghu, Wang, Yubao, Jiang, Baishan, Li, Qing, Buckley, Dennis L, Nabet, Behnam, Roberts, Justin M, Paulk, Joshiawa, Dastjerdi, Shiva, Winter, Georg E, McLauchlan, Hilary, Moran, Jennifer, Bradner, James E, Eck, Michael J, Dhe-Paganon, Sirano, Zhao, Jean J, Gray, Nathanael S
Gepubliceerd in eLife (2017)