Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and T...

Por Chan, Kwok-Ho, Zengerle, Michael, Testa, Andrea, Ciulli, Alessio
Publicado no J Med Chem (2017)

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements

Por Morreale, Francesca E., Testa, Andrea, Chaugule, Viduth K., Bortoluzzi, Alessio, Ciulli, Alessio, Walden, Helen
Publicado no J Med Chem (2017)

Structural basis of PROTAC cooperative recognition for selective protein degradation

Por Gadd, Morgan S., Testa, Andrea, Lucas, Xavier, Chan, Kwok-Ho, Chen, Wenzhang, Lamont, Douglas J., Zengerle, Michael, Ciulli, Alessio
Publicado no Nat Chem Biol (2017)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Por Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio
Publicado no Nat Commun (2017)