Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Cyclin dependent kinase 9 (CDK9), a key regulator of transcriptional elongation, is a promising target for cancer therapy, particularly for cancers driven by transcriptional dysregulation. Here, we report the characterization of NVP-2 (3), a selective ATP-competitive CDK9 inhibitor; and THAL-SNS-032...

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Udgivet i:Nat Chem Biol
Main Authors: Olson, Calla M., Jiang, Baishan, Erb, Michael A., Liang, Yanke, Doctor, Zainab M., Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L., Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S., Young, Richard A., Bradner, James E., Winter, Georg E., Gray, Nathanael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912898/
https://ncbi.nlm.nih.gov/pubmed/29251720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2538
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