Activation of the p53 transcriptional program sensitizes cancer cells to Cdk7 inhibitors

Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. However, whereas selective inhibition of analog-sensitive (AS) Cdk7 in colon cancer-derived cells arrests division and d...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Kalan, Sampada, Amat, Ramon, Schachter, Miriam Merzel, Kwiatkowski, Nicholas, Abraham, Brian J., Liang, Yanke, Zhang, Tinghu, Olson, Calla M., Larochelle, Stéphane, Young, Richard A., Gray, Nathanael S., Fisher, Robert P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687273/
https://ncbi.nlm.nih.gov/pubmed/29020632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.056
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