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Activation of the p53 transcriptional program sensitizes cancer cells to Cdk7 inhibitors
Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. However, whereas selective inhibition of analog-sensitive (AS) Cdk7 in colon cancer-derived cells arrests division and d...
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| 發表在: | Cell Rep |
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| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687273/ https://ncbi.nlm.nih.gov/pubmed/29020632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.056 |
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