A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

Eukaryotic cell division is controlled by cyclin-dependent kinases (CDKs), which require phosphorylation by a CDK-activating kinase (CAK) for full activity. Chemical genetics uncovered requirements for the metazoan CAK Cdk7 in determining cyclin-specificity and activation order of Cdk2 and Cdk1 duri...

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Autores principales: Schachter, Miriam Merzel, Merrick, Karl A., Larochelle, Stéphane, Hirschi, Alexander, Zhang, Chao, Shokat, Kevan M., Rubin, Seth M., Fisher, Robert P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677717/
https://ncbi.nlm.nih.gov/pubmed/23622515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.04.003
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