Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells

Cell division is controlled by cyclin-dependent kinases (CDKs). In metazoans, S-phase onset coincides with activation of Cdk2, whereas Cdk1 triggers mitosis. Both Cdk1 and -2 require cyclin-binding and T-loop phosphorylation for full activity. The only known CDK-activating kinase (CAK) in metazoans...

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Main Authors: Larochelle, Stéphane, Merrick, Karl A., Terret, Marie-Emilie, Wohlbold, Lara, Barboza, Nora M., Zhang, Chao, Shokat, Kevan M., Jallepalli, Prasad V., Fisher, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858677/
https://ncbi.nlm.nih.gov/pubmed/17386261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.02.003
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