Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells

The cyclin-dependent kinases (CDKs) that promote cell-cycle progression are targets for negative regulation by signals from damaged or unreplicated DNA, but also play active roles in response to DNA lesions. The requirement for activity in the face of DNA damage implies that there are mechanisms to...

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主要な著者: Wohlbold, Lara, Merrick, Karl A., De, Saurav, Amat, Ramon, Kim, Jun Hyun, Larochelle, Stéphane, Allen, Jasmina J., Zhang, Chao, Shokat, Kevan M., Petrini, John H. J., Fisher, Robert P.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426557/
https://ncbi.nlm.nih.gov/pubmed/22927831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002935
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