Distinct Activation Pathways Confer Cyclin Binding Specificity on Cdk1 and Cdk2 in Human Cells

In metazoans, different cyclin-dependent kinases (CDKs) bind preferred cyclin partners to coordinate cell division. Here we investigate these preferences in human cells, and show that cyclin A assembles with Cdk1 only after complex formation with Cdk2 reaches a plateau, in late S and G2 phases. To u...

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Hlavní autoři: Merrick, Karl A., Larochelle, Stéphane, Zhang, Chao, Allen, Jasmina J., Shokat, Kevan M., Fisher, Robert P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643088/
https://ncbi.nlm.nih.gov/pubmed/19061641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.10.022
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