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Distinct Activation Pathways Confer Cyclin Binding Specificity on Cdk1 and Cdk2 in Human Cells
In metazoans, different cyclin-dependent kinases (CDKs) bind preferred cyclin partners to coordinate cell division. Here we investigate these preferences in human cells, and show that cyclin A assembles with Cdk1 only after complex formation with Cdk2 reaches a plateau, in late S and G2 phases. To u...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643088/ https://ncbi.nlm.nih.gov/pubmed/19061641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.10.022 |
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