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Separate Domains of Fission Yeast Cdk9 (P-TEFb) Are Required for Capping Enzyme Recruitment and Primed (Ser7-Phosphorylated) Rpb1 Carboxyl-Terminal Domain Substrate Recognition

In fission yeast, discrete steps in mRNA maturation and synthesis depend on a complex containing the 5′-cap methyltransferase Pcm1 and Cdk9, which phosphorylates the RNA polymerase II (Pol II) carboxyl-terminal domain (CTD) and the processivity factor Spt5 to promote transcript elongation. Here we s...

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Detalhes bibliográficos
Main Authors: St. Amour, Courtney V., Sansó, Miriam, Bösken, Christian A., Lee, Karen M., Larochelle, Stéphane, Zhang, Chao, Shokat, Kevan M., Geyer, Matthias, Fisher, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434489/
https://ncbi.nlm.nih.gov/pubmed/22508988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06657-11
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