P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

The transcription cycle of RNA polymerase II (Pol II) is regulated at discrete transition points by cyclin-dependent kinases (CDKs). Positive transcription elongation factor b (P-TEFb), a complex of Cdk9 and cyclin T1, promotes release of paused Pol II into elongation, but the precise mechanisms and...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Sansó, Miriam, Levin, Rebecca S., Lipp, Jesse J., Wang, Vivien Ya-Fan, Greifenberg, Ann Katrin, Quezada, Elizabeth M., Ali, Akbar, Ghosh, Animesh, Larochelle, Stéphane, Rana, Tariq M., Geyer, Matthias, Tong, Liang, Shokat, Kevan M., Fisher, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701974/
https://ncbi.nlm.nih.gov/pubmed/26728557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.269589.115
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