A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast

Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood. Mono-ubiquitylation of histone H2B (H2Bub1) plays...

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Detalhes bibliográficos
Main Authors: Sansó, Miriam, Lee, Karen M., Viladevall, Laia, Jacques, Pierre-Étienne, Pagé, Viviane, Nagy, Stephen, Racine, Ariane, St. Amour, Courtney V., Zhang, Chao, Shokat, Kevan M., Schwer, Beate, Robert, François, Fisher, Robert P., Tanny, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410854/
https://ncbi.nlm.nih.gov/pubmed/22876190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002822
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